COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 1 22:58 Thursday, November 17, 2005 The LIFETEST Procedure Summary of the Number of Censored and Uncensored Values Percent Stratum group Total Failed Censored Censored 1 Control 15 15 0 0.00 2 Treated 20 20 0 0.00 --------------------------------------------------------------- Total 35 35 0 0.00 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 2 22:58 Thursday, November 17, 2005 The LIFETEST Procedure Survival Function Estimates S SDF | u 1.0 + *-----* r | *C---T v | C---*----------------TT i | C---C T-T v | CC T a | C----C TT l | | T-TT | C--C | D 0.5 + | T-T i | C----------C T s | C-**--------C t | TT C--C r | T-T C----C i | T-T CC b | T---T C-C u | T-----T CC t 0.0 + T C i ----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+---- o 0 10 20 30 40 50 60 70 80 90 100 n time COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 3 22:58 Thursday, November 17, 2005 The LIFETEST Procedure -Log(Survival Function) Estimates -LOG SDF | N 3 + T e | ++ C g | + + a | T + t | + + i 2 + + C v | + + e | +T ++C | T C++ L | T ++ o 1 + +++++C+*+++++++++C g | +C+++++ +T | ++C+ +TT S | ++CC++ TT D | C+++*++++++++++++++++TT+T F 0 + *+++++*++ | --+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+- 0 10 20 30 40 50 60 70 80 90 100 time COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 4 22:58 Thursday, November 17, 2005 The LIFETEST Procedure Legend for Strata Stratum Symbol group 1 C Control 2 T Treated COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 5 22:58 Thursday, November 17, 2005 The LIFETEST Procedure Testing Homogeneity of Survival Curves for time over Strata Rank Statistics group Log-Rank Wilcoxon Control -2.7682 25.000 Treated 2.7682 -25.000 Covariance Matrix for the Log-Rank Statistics group Control Treated Control 6.80999 -6.80999 Treated -6.80999 6.80999 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 6 22:58 Thursday, November 17, 2005 The LIFETEST Procedure Covariance Matrix for the Wilcoxon Statistics group Control Treated Control 3440.50 -3440.50 Treated -3440.50 3440.50 Test of Equality over Strata Pr > Test Chi-Square DF Chi-Square Log-Rank 1.1253 1 0.2888 Wilcoxon 0.1817 1 0.6700 -2Log(LR) 0.0446 1 0.8328 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 7 PHREG FOR TWO SAMPLES 22:58 Thursday, November 17, 2005 The PHREG Procedure Model Information Data Set WORK.TWOSAMP Dependent Variable time Censoring Variable status Censoring Value(s) 1 Ties Handling BRESLOW Number of Observations Read 35 Number of Observations Used 35 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 35 35 0 0.00 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 184.866 183.739 AIC 184.866 185.739 SBC 184.866 187.294 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 1.1270 1 0.2884 Score 1.1018 1 0.2939 Wald 1.0899 1 0.2965 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio treat 1 0.41290 0.39550 1.0899 0.2965 1.511 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 8 PROC PHREG WITH A TIME-DEPENDENT COORDINATE 22:58 Thursday, November 17, 2005 The PHREG Procedure Model Information Data Set WORK.TWOSAMP Dependent Variable time Censoring Variable status Censoring Value(s) 1 Ties Handling BRESLOW Number of Observations Read 35 Number of Observations Used 35 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 35 35 0 0.00 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 184.866 172.465 AIC 184.866 176.465 SBC 184.866 179.576 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 12.4011 2 0.0020 Score 13.1048 2 0.0014 Wald 10.0801 2 0.0065 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio treat 1 -2.54666 1.06740 5.6923 0.0170 0.078 trttime 1 0.05919 0.01957 9.1532 0.0025 1.061 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 9 RATES FOR TIME<=50 ONLY: ALL TIMES>50 ARE CENSORED 22:58 Thursday, November 17, 2005 The PHREG Procedure Model Information Data Set WORK.CENSAFTER50 Dependent Variable time Censoring Variable status Censoring Value(s) 1 Ties Handling BRESLOW Number of Observations Read 35 Number of Observations Used 35 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 35 12 23 65.71 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 81.190 76.830 AIC 81.190 78.830 SBC 81.190 79.315 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 4.3601 1 0.0368 Score 4.5583 1 0.0328 Wald 4.0344 1 0.0446 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio treat 1 -1.23700 0.61585 4.0344 0.0446 0.290 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 10 RATES FOR TIMES>50 ONLY: ALL TIMES<50 ARE CENSORED 22:58 Thursday, November 17, 2005 The PHREG Procedure Model Information Data Set WORK.CENSBEFORE50 Dependent Variable time Censoring Variable status Censoring Value(s) 1 Ties Handling BRESLOW Number of Observations Read 35 Number of Observations Used 35 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 35 23 12 34.29 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 103.676 93.096 AIC 103.676 95.096 SBC 103.676 96.232 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 10.5801 1 0.0011 Score 9.5417 1 0.0020 Wald 7.8749 1 0.0050 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio treat 1 1.85563 0.66126 7.8749 0.0050 6.396 COMPARE TWO SAMPLES -- COX PH MODEL - YOURNAME 11 TWO HAZARD-RATE TIERS BY PROGRAMMING STATEMENTS 22:58 Thursday, November 17, 2005 The PHREG Procedure Model Information Data Set WORK.TWOSAMP Dependent Variable time Censoring Variable status Censoring Value(s) 1 Ties Handling BRESLOW Number of Observations Read 35 Number of Observations Used 35 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 35 35 0 0.00 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 184.866 169.926 AIC 184.866 173.926 SBC 184.866 177.037 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 14.9401 2 0.0006 Score 14.1000 2 0.0009 Wald 11.9112 2 0.0026 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio early 1 -1.23736 0.61589 4.0363 0.0445 0.290 late 1 1.85563 0.66126 7.8749 0.0050 6.396