Prof. Sarah Holte

Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics

Title: Analysis and Design of Viral Dynamics Studies

Abstract:
In recent years, investigators have used systems of differential equations to evaluate pathogenesis due to HIV-1 infection in humans. The statistical methods used with these studies are either nonexistent or very simple. In this talk, alternative methods of parameter estimation for studies where estimation of parameters in systems of differential equations from longitudinal data is required. In addition, methods which can be used to design studies of this type will be described.