- The final examination is now
available. It is due on Friday, May 1st, 2020, at 4:00pm CDT.
- Because of the heightened dependence on technology this semester,
unexpected problems such as internet interruptions and device failures
have created inequities. I wish to compensate for these inequities in
a manner fair to all by way of this updated HW grading policy:
HWs 1 through 6 will together count for 30% of the course score.
HWs 7 through 11 will together count for 10% of the course score.
Any submitted HW of these last five will be accepted and graded.
Those with CrowdMark tech problems may email me their HW as
attached PDFs or JPEGs or text files.
Example R commands for:
- mean and median r-eg-01.txt.
- histograms and samples r-eg-02.txt.
- deviation and diversity r-eg-03.txt.
- combinations and permutations r-eg-04.txt.
- box plots and confidence intervals r-eg-05.txt.
- use, power and sample size in t tests r-eg-06.txt.
- Student-t test power demo r-eg-33.txt
- Student-t tests from reduced data r-eg-34.txt
- multinomial pdf calculation and sampling r-eg-30.txt.
- Dirichlet pdf plotting in 3 variables r-eg-35.txt.
- Matrix entry; Mann-Whitney, Wilcoxon, McNemar, and median
comparison tests r-eg-07.txt.
- single-factor analysis of variance with unequal
- multiple comparison of means r-eg-09.txt.
- homoscedasticity tests r-eg-10.txt.
- two- and three-factor ANOVA r-eg-11.txt.
- MANOVA demo r-eg-12.txt.
- bivariate normal density estimation, sampling, and plotting with
persp() and contour() r-eg-13.txt.
- simple linear regression r-eg-14.txt.
- simple correlation r-eg-15.txt.
- multiple linear regression and prediction r-eg-16.txt.
- Kendall's W r-eg-17.txt.
- partial correlation coefficients r-eg-18.txt.
- goodness of fit r-eg-19.txt.
- tests of independence in contingency tables r-eg-20.txt.
- Fisher's exact test r-eg-21.txt.
- binomial and hypergeometric densities r-eg-22.txt.
- Poisson density and one randomness test r-eg-23.txt.
- tests of serial randomness r-eg-24.txt.
- installing the contributed package "tseries" r-eg-25.txt.
- Gibbs sampling ma322-02-28-Rcode.txt (from the February
28th, 2011 lecture).
- rejection, Metropolis, and Metropolis-Hastings sampling
metroph.txt (from the March 2nd, 2011 lecture).
- GenBank data and goodness of fit
(from the March 30th, 2011 lecture).
- multivariate visualization, principal components, Mahalanobis
distance, and linear discriminant analysis r-eg-26.txt.
- classification trees, with gene data clean-up r-eg-27.txt.
- clustering by means, medoids, agglomerative and divisive trees r-eg-28.txt.
- multidimensional scaling by IsoMap r-eg-29.txt.
- bootstrap method to estimate sampling error in non-normal PDFs r-eg-32.txt.
- How normal random variables combine to give chi-squared and F densities r-eg-36.txt.
- Example Midterm (2016).
- Open-source software R
for statistical computing, and its manual.
- Download R from WUStL's software
Studio from its developer's website.
- Download a precompiled executable Maxima, for Windows,
- Maxima project home page,
for sources, documentation, links, and precompiled binary downloads for Linux,
Macintosh and other systems.
- Download old free MatLab (for
Windows or Linux PCs) from my website.
- There is an online Octave
to R dictionary, useful
for those who know MatLab or Octave well and want to learn the
corresponding R commands.
- R program in file deduct.R to solve HW 1's DNA
sequence counting problem.
- R program in file faker.R. Then "faker(n, mu, sd)"
generates n>1 samples with exact prescribed mean mu and exact standard
- Notes (brillouin.pdf) on Brillouin
and Shannon diversity, for HW 1.
- Notes (condprob.pdf) on conditional
probabilities and continuous densities, for HW 3.
- R program in file bvnpdf.R,
to compute bivariate normal pdfs. Read the code for usage instructions.
- R program in file dagopear.R to perform
the D'Agostino-Pearson test of normality and compute the associated
R program in file cochran.R for Cochran's test of a
dichotomous variable without replication.
R program in file kendall.w.R to compute Kendall's
coefficient of concordance (Kendall's W). Call it using
where tab is a matrix with scores (or ranks) along its rows.
- NCI microarray data on 14 cancers:
- nci.info: some information on the data
- nci.names: just the 64 names identifying
14 cancers, to label the 64 rows of gene expression data.
- nci.data: gene expression data, 64 rows
of 6830 gene expression values. HINT: Save this to a file.
- Cleaned-up NCI microarray data, 57 samples of 8 cancers with top
12 expressed genes: nci57x13.R, to be saved
into your R folder and read into the R session with
load("nci57x13.R"). The result is a data frame named "nci12".
- Download nci57x7.R and
load("nci57x7.R") to get the top 6 genes data. The result is a
data frame named "nci6".
- Download nci57x6831.R and
load("nci57x6831.R") to get the full gene expression data frame,
named simply "nci".
- Article and Table
1 on ABO blood types and cancer in Northern India, for the term project.
- WinBUGS and tutorials:
- Saed Sayad's notes on classifier evaluation:
Topics. This is a second course in applied statistics with
examples from biology and medicine. Topics include Bayes rule, Markov
chains, maximum likelihood estimation with MCMC, classical statistical
inference, ANOVA and MANOVA, multivariate visualization, multiple
regression, correlation, and classification. Each student will NO
LONGER BE REQUIRED to perform and write a report on a
data analysis project.
Prerequisites. Math 3200, or Math 2200 and the permission of
Time. Classes meet Mondays, Wednesdays and Fridays, 3:00pm
to 3:50pm, in Cupples I Hall room 113.
Text. The lectures will follow
Statistics Using R with Biological
Examples by Kim Seefeld and Ernst Linder, an e-text that you
may download freely. (Alternative
If you desire a paper copy, you may have it
printed and bound at any copy shop from this PDF file.
Supplementary readings and software may be found in the "LINKS" column above.
Homework. You are encouraged to collaborate on homework,
although each student must turn in solutions individually. Please
complete your solutions on CrowdMark by 11pm on the due date.
For full credit, homework solutions should be clearly legible with the
answers properly labeled. For computations, include the R commands
used, the input provided, and the output with
labels indicating which part of the solution is thus computed.
Suggestion: copy and paste your R session into a text editing
program and delete unnecessary text and space, then comment and
annotate as needed. Hand in homework as you would like to
get it if you were the grader.
will be assigned as follows:
Solutions, via CrowdMark, are due at 11:00pm on the due date. Late homework
will not be accepted.
- HW #1, due Fri, Jan 24
- HW #2, due Fri, Jan 31
- HW #3, due Fri, Feb 7
- HW #4, due Fri, Feb 14
- HW #5, due Fri, Feb 21
- HW #6, due Fri, Feb 28
- HW #7, due Fri, Mar 27
- HW #8, due Fri, Apr 3
- HW #9
(hw09data.txt), due Fri, Apr 10
- HW #10 (hw10data.txt), due Fri, Apr 17
- HW #11, due Fri, Apr 24 (last class)
Tests. There will be one midterm examination in class on
Wednesday, March 4th, 2020. No reference
material or electronic devices will be allowed.
There will be one cumulative take-home final
examination, emphasizing the later material. It is due on
Friday, May 1st, 2020, by 4:00pm, on CrowdMark.
Grading. One score will be assigned for homework, one for the
midterm examination, and one for the final examination. These three
will contribute in respective shares of 40% (30% for HWs 1-6,
10%for HWs 7-11), 30%, and 30% to the
course score. Letter grades, computed from the course score,
will be at least the following:
|Course score at least:||90%||80%||70%||60%||Letter grade at least:||A||B||C||D
Students taking the Cr/NCr or P/F options will need a grade of D or better to
pass. Students taking the Audit option will need to attend 36 of the
40 class meetings to obtain a Successful Audit grade.
Computing. Students are encouraged to use R on their own computers or on
the computers available in the Arts and Sciences Computing
Center for both symbolic and numerical computations.
Office Hours. Mondays and Wednesdays 2:00-3:00pm (before
class), Fridays 4:00-5:00pm (after class), or by appointment.
Questions? Return to
M. Victor Wickerhauser's home page for contact information.